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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/13113

Title: Hepatoprotective Potential of Hura crepitans L.: A Review of Ethnomedical, Phytochemical and Pharmacological Studies
Authors: Owojuyigbe, Oluwole S.
Firempong, Caleb K.
Larbie, Christopher
Komlaga, Gustav
Emikpe, Benjamin O.
Keywords: Hura crepitans L.
toxicological assessment
; phytochemical properties
; hepato-protection
Issue Date: Mar-2020
Publisher: Journal of Complementary and Alternative Medical Research
Citation: Journal of Complementary and Alternative Medical Research, 9(2): 1-10,
Abstract: Herbal medicines are the main source of treatment of diseases in non-urban centres of the developing world. Secondary metabolites obtained from herbal sources contain bioactive phytochemicals, many of which have been the origin for the development of novel pharmaceutical drugs. Hura crepitans L. (Euphorbiaceae) or sandbox tree has been beneficial in many ethnomedicinal applications as a purgative, emetic, hepatoprotective, anti-inflammatory, antimicrobial and the treatment of leprosy. Toxicological, phytochemical and bactericidal studies have also been documented. This paper reviews the potential of the Hura crepitans plant in protecting the liver against drug-induced toxicity. The paper dwells extensively on the ethnomedical, phytochemical and pharmacological properties of the plant. In achieving the above, intensive analyses of books and published peer-reviewed journal articles were carried out using credible scientific databases. Four main phytochemicals were revealed to be contained in Hura crepitans stem-bark. Their protective effects were enunciated using animal models. However much more biochemical studies need to be done to establish the hepatoprotective potentials of the various parts and various phytochemicals of Hura crepitans with the need for more preclinical and clinical studies. We, therefore, present in this paper efforts to elucidate and bring to the fore the therapeutic potentials of Hura crepitans plant.
Description: This article is published in Journal of Complementary and Alternative Medical Research and also available at 10.9734/JOCAMR/2020/v9i230136
URI: 10.9734/JOCAMR/2020/v9i230136
Appears in Collections:College of Science

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