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|Title: ||Griffonia simplicifolia (DC.) Baill. attenuates gentamicin and cisplatin-induced nephrotoxicty in rats|
|Authors: ||Larbie, Christopher|
Nyarko, Ruby A.
Anning, Alexander K.
Baidoo, Philip K.
Emikpe, Benjamin O.
Oyagbemi, Ademola A.
Jarikre, Theophilus A.
|Keywords: ||Griffonia simplicifolia|
|Issue Date: ||14-Mar-2019|
|Publisher: ||Comparative Clinical Pathology|
|Citation: ||Comparative Clinical Pathology|
|Abstract: ||Nephrotoxicity is one of the most common kidney conditions. However, most conventional drugs are not
adequate for treatment. This study was designed to evaluate the nephroprotective activity of 50% hydroethanolic
leaf extract of Griffonia simplicifolia (DC.) Benth in drug-induced nephrotoxicity in Sprague–Dawley rats.
Nephrotoxicity was induced in experimental animals by administering gentamicin and cisplatin after pretreatment
with hydroethanolic extract of G. simplicifolia (GSE). GSE at 100 and 250 mg/kg were administered
for 7 and 10 days by oral gavage in the gentamicin and cisplatin models, respectively. Silymarin (120 mg/kg)
was given as the standard nephroprotective drug. Nephroprotective effect was studied by assaying the activity of
kidney function biomarkers such as creatinine, urea, sodium, chloride, and potassium concentrations. The effect
of the treatments on kidney antioxidant enzymes (SOD, MDA, GSH, GPx, GST and NO), inflammatory cytokines
(IL 17, IL 23 and COX-2) and the histology of the kidney were also examined. The activity of all the
kidney function biomarkers changed significantly in gentamicin and cisplatin-treated rats; increased in urea and
creatinine concentration and decreased in Na, K and Cl concentrations. Co-administration of GSE with the
nephrotoxins restored these to normal levels. It also reduced NO concentration in both the gentamicin and
cisplatin model and increased GPx concentration in the gentamicin model. GSE showed a higher percentage
protection than silymarin, a standard nephroprotective drug, in both the gentamicin and cisplatin models.
Intensity of structural alterations revealed that the GSE treatments have a protective potential against nephrotoxicity.
GSE treatments improved expressions of IL17 and IL23, thus underscoring the proinflammatory and
healing properties of GSE, respectively. The results generally indicate that leaves of G. simplicifolia possess
|Description: ||This article has been published by Comparative Clinical Pathology and is available at https://doi.org/10.1007/s00580-019-02934-x|
|Appears in Collections:||College of Science|
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