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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12907

Title: Secondary metabolites from two phenotypic variants of colletotrichum gloeosporioides show antibacterial and antioxidant activities
Authors: Mensah, John Kenneth
Kwoseh, Charles
Adjei, Stephen
Ampomah, Kwadwo
Dankwa, Adwoa Safoa
et. al
Keywords: Colletotrichum gloeosporioides
Secondary metabolites
Antibiotics
Antioxidants
Fungi
Issue Date: Oct-2018
Publisher: International Scientific Organization
Citation: J. K. Mensah, C. Kwoseh, S. Adjei, K. Ampomah, A. S. Dankwa, C. Anamoah and A. Yesman. Secondary metabolites from two phenotypic variants of colletotrichum gloeosporioides show antibacterial and antioxidant activities. Current Science Perspectives 4(4) (2018) 48-57.
Abstract: Crude polar and nonpolar extracts of the secondaray metabolites of the sabouraud broth pure cultures of two genetically identical but phenotypically distinct strains of Colletotrichum gloeosporioides were tested for antimicrobial and antioxidants activities in vitro. Extracts from both Colletotrichum gloeosporioides (Black sp.) and Colletotrichum gloeosporioides (White sp.) showed the presence of unique solvent-dependent combinations of multiple phytochemicals that included terpenoids, flavonoids, anthraquinones, tannis and saponins. For both Colletotrichum gloeosporioides (Black sp.) and Colletotrichum gloeosporioides (White sp.) strains, crude polar fungal extracts recorded higher antibacterial activities against the panel of 9 tested bacterial pathogens than did the nonpolar extract in the agar diffusion assay (relatively larger zone diameters of inhibition) and in the broth dilution assay (relatively lower MICs). Polar extracts of both fungal metabolites were also stronger antioxidants than the nonpolar extracts and displayed in both cases IC50s in DPPH radical scavenging assays that were at least 3-fold difference lower than that of their corresponding nonpolar extracts. But the DPPH radical scavenging antioxidant activities of both fungal extracts were meagre compared to that of the Ascorbic acid control as both extracts showed IC50s that were at least 6-fold difference higher than that of Ascorbic acid. Future studies can assess the potential of single purified secondary metabolites from either Colletotrichum gloeosporioides (White sp.) or Colletotrichum gloeosporioides (Black sp.) or from both fungi to act as leads for the development of novel antibacterial agents.
Description: An article published by International Scientific Organization
URI: http://hdl.handle.net/123456789/12907
Appears in Collections:College of Science

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