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|Title: ||Genomic analyses in African populations identify novel risk loci for cleft palate|
|Authors: ||Butali, Azeez|
Mossey, Peter A.
Adeyemo, Wasiu L.
Eshete, Mekonen A.
Gowans, Lord J.J.
|Issue Date: ||2018|
|Publisher: ||Oxford University Press 2018.|
|Abstract: ||Orofacial clefts are common developmental disorders that pose significant clinical, economical and psychological problems.
We conducted genome-wide association analyses for cleft palate only (CPO) and cleft lip with or without palate (CL/P) with
∼17 million markers in sub-Saharan Africans. After replication and combined analyses, we identified novel loci for CPO at or
near genome-wide significance on chromosomes 2 (near CTNNA2) and 19 (near SULT2A1). In situ hybridization of Sult2a1 in
mice showed expression of SULT2A1 in mesenchymal cells in palate, palatal rugae and palatal epithelium in the fused
palate. The previously reported 8q24 was the most significant locus for CL/P in our study, and we replicated several
previously reported loci including PAX7 and VAX1.|
|Description: ||An article published by Oxford University Press 2018. and also available at doi: 10.1093/hmg/ddy402|
|Appears in Collections:||College of Science|
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