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|Title: ||The association between micronutrients levels and gestational diabetes: A cross sectional study in Ashanti region|
|Authors: ||Ataanya, Daniel Abera|
|Issue Date: ||26-Nov-2018|
|Publisher: ||International Journal of Biochemistry Research & Review|
|Abstract: ||Aims: Micronutrients such as chromium, iron, magnesium and zinc can serve as good therapeutic
and preventive agents for several diabetes complications including Gestational Diabetes Mellitus
(GDM). The aim of this study was to compare the serum levels of chromium, iron, zinc and
magnesium in pregnant women with and without GDM and to assess the association between the
levels of these minerals and GDM.
Study Design: A cross-sectional study.
Place and Duration of Study: Antenatal clinics in five selected hospitals in Ashanti region of
Ghana between August 2016 to August 2017.
Methodology: A total of 50 pregnant women with GDM and 50 controls of the same gestational
age participated in the study. A structured questionnaire was used to collect information on
demographic and clinical characteristics. Standard oral glucose tolerance test was used to measure glucose profile. Serum levels of chromium, iron, zinc and magnesium were measured
using the atomic absorption spectrophotometer (AAS).
Results: The results indicated that 14% of the respondents with GDM had a previous history of
gestational diabetes. However, there was no previous history among the control group. Serum zinc
was not significantly different in the two groups (0.052 ± 0.01 mg/dl; 0.093 ± 0.03 mg/dl, p=0.276).
Iron levels in the GDM group were high (0.956 ± 0.35 mg/dl) compared with the control group
(0.635± 0.41 mg/dl). There was no significant difference of the serum magnesium level in the two
groups (p=0.967). Chromium was higher in the GDM group (0.051±0.05) than the control group
(0.012±0.06). There was a significant positive correlation between iron (r = 0.303, p = 0.000) and
chromium (r = 0.302, p= 0.002) with the markers of GDM.
Conclusion: The study showed that high serum concentration of iron is associated with
hyperglycemia. Serum magnesium and zinc levels did not exhibit any significant differences
between GDM women and nondiabetic women. It is recommended that micronutrients
supplementation during pregnancy needs to be carefully examined and commence only when
significant deficiencies are observed.|
|Description: ||An article published by International Journal of Biochemistry Research & Review and also available at DOI: 10.9734/IJBCRR/2018/45107|
|Appears in Collections:||College of Science|
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