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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12737

Title: Seroprevalence, risk factors and impact of Toxoplasma gondiiinfection on haematological parameters in the Ashanti region ofGhana: a cross-sectional study[version 1; peer review: 1approved with reservations]
Authors: Agordzo, Samuel Kekeli
Badu, Kingsley
Addo, Mathew Glover
Owusu, Christian Kwasi
Mutala, Abdul-Hakim
et. al
Keywords: Toxoplasma gondii
Haematology
Seroprevalence
IgG
Exposure
Risk Factors
Issue Date: 26-Nov-2019
Publisher: AAS Open Research
Citation: Agordzo SK, Badu K, Addo MG How to cite this article:et al.Seroprevalence, risk factors and impact of infection onToxoplasma gondiihaematological parameters in the Ashanti region of Ghana: a cross-sectional study [version 1; peer review: 1 approved with AAS Open Research 2019, :166 ()reservations]2https://doi.org/10.12688/aasopenres.13022.1
Abstract: Background: Toxoplasma gondiiparasite that causes toxoplasmosis. Although the global prevalence oftoxoplasmosis has been estimated to be approximately 30%, there islimited seroprevalence data in Ghana, with a dearth of information on theimpact of on haematological parameters in exposed persons.T. gondiiQuestionnaires were administered to 300 consenting individualsMethods: to obtain demographic information and assessment of their risk of exposureto . Using anti-IgG/IgM combo test kits, seropositivity toT. gondiiT. gondii parasite-specific IgG and/or IgM was determined. A haematologicalanalyser was used to measure haematological parameters.The participants included 58 males and 242 females, and rangedResults: in age from 6 months to 84 years, with a median age of 27 years. There wasan overall seroprevalence of 50.3% (n=151), with 49.7% (n=149) of thestudy participants seropositive for IgG and 1% (n=3) testing positive forIgM. Furthermore, the observed seroprevalence among pregnant womenwas 56.4% (n=62). With regards to the different communities in which thehospitals were located, a seroprevalence of 55.6% was observed in therural community, 50.6% in the peri-urban community and 47.1% in theurban community. The study identified cat ownership, contact with cat litter[RR (95% CI: 1.76 (1.23-2.53), 1.66 (1.03-2.67), 1.25(1.00-1.57)] and age(p<0.001) as risk factors for infection. Analyses of haematological data alsorevealed significant differences between the red blood cell counts(p=0.038) and mean corpuscular volumes (p=0.0007) of seropositive andseronegative study participants. About half of the study population, including a significantConclusions:number of women of reproductive age carried antibodies against ,T. gondii
Description: An article published by AAS Open Research and also available at https://doi.org/10.12688/aasopenres.13022.1
URI: http://hdl.handle.net/123456789/12737
Appears in Collections:College of Science

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