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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12724

Title: Immunity in filarial infections: lessons from animal models and human studies
Authors: Kwarteng, Alexander
Ahuno, S. T.
Issue Date: 2017
Publisher: Scandinavian Journal of Immunology
Abstract: Our understanding of immunity to filarial infection is enigmatic and continuesto be passionately debated. The mechanisms whereby filarial nematodes are killedin vivoand how these parasites avoid these mechanisms are poorly understood.Although vaccination studies in permissive animals took off seven decades ago,the exact mechanisms driving protective immunity are extensively beinginvestigated. Currently, little is known regarding the collective functions orcounter-regulatory mechanisms of the antibody isotypes in filarial infection withrespect to protective immunity. Establishing the functional role of antibodyisotypes and cytokines in the various infection phenotypes can contributeimmensely to current knowledge in filarial immunology. This paper reviewsinsight into protective immunity in filarial infection with focus on humoral andcellular responses from animal models and human studies.
Description: An article published by Scandinavian Journal of Immunology and also available at doi: 10.1111/sji.12533
URI: http://hdl.handle.net/123456789/12724
Appears in Collections:College of Science

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