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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12722

Title: The potentials and pitfalls of microarraysin neglected tropical diseases: A focus on human filarial infections
Authors: Kwarteng, Alexander
Ahuno, Samuel Terkper
Keywords: microarray
transcriptomics
filarial
whole blood
signaling pathways
Issue Date: 2-Aug-2016
Publisher: MDPI
Abstract: Data obtained from expression microarrays enables deeper understanding of the molecular signatures of infectious diseases. It provides rapid and accurate information on how infections affect the clustering of gene expression profiles, pathways and networks that are transcriptionally active during various infection states compared to conventional diagnostic methods, which primarily focus on single genes or proteins. Thus, microarray technologies offer advantages in understanding host-parasite interactions associated with filarial infections. More importantly, the use of these technologies can aid diagnostics and helps translate current genomic research into effective treatment and interventions for filarial infections. Studying immune responses via microarray following infection can yield insight into genetic pathways and networks that can have a profound influence on the development of anti-parasitic vaccines.
Description: An article published by MDPI and also available at doi:10.3390/microarrays5030020
URI: http://hdl.handle.net/123456789/12722
Appears in Collections:College of Science

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