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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12718

Title: Wuchereria bancrofti-infected individuals harbor distinct IL-10-producing regulatory B and T cell subsets which are affected by anti-filarial treatment
Authors: Ritter, Manuel
Osei-Mensah, Jubin
Debrah, Linda Batsa
Kwarteng, Alexander
Mubarik, Yusif
et. al
Issue Date: 23-May-2019
Publisher: PLoSNegl Trop Dis
Citation: RitterM, Osei-Mensah J, DebrahLB,KwartengA, MubarikY, DebrahAY, et al. (2019)Wuchereria bancrofti-infected individualsharbordistinctIL-10-producing regulatoryB and T cellsubsetswhichare affectedby anti-filarialtreatment.PLoSNegl Trop Dis 13(5):e0007436.https://doi.org/10.1371/journal.pntd.0007436
Abstract: Despite worldwide mass drug administration, it is estimated that 68 million individuals are still infected with lymphatic filariasis with 19 million hydrocele and 17 million lymphedema reported cases. Despite the staggering number of pathology cases, the majority of LFinfected individuals do not develop clinical symptoms and present a tightly regulated immune system characterized by higher frequencies of regulatory T cells (Treg), suppressed proliferation and Th2 cytokine responses accompanied with increased secretion of IL-10, TGF-β and infection-specific IgG4. Nevertheless, the filarial-induced modulation of the host‘s immune system and especially the role of regulatory immune cells like regulatory B (Breg) and Treg during an ongoing LF infection remains unknown. Thus, we analysed Breg and Treg frequencies in peripheral blood from Ghanaian uninfected endemic normals (EN), lymphedema (LE), asymptomatic patent (CFA+MF+) and latent (CFA+MF-)W. bancrofti- infected individuals as well as individuals who were previously infected withW. bancrofti (PI) but had cleared the infection due to the administration of ivermectin (IVM) and albendazole (ALB). In summary, we observed that IL-10-producing CD19+CD24highCD38- dhigh Breg were specifically increased in patently infected (CFA+MF+) individuals. In addition, CD19+CD24highCD5+CD1dhigh and CD19+CD5+CD1dhighIL-10+ Breg as well as CD4+CD127-FOXP3+ Treg frequencies were significantly increased in bothW. bancroftiinfected cohorts (CFA+MF+ and CFA+MF-). Interestingly, the PI cohort presented frequency levels of all studied regulatory immune cell populations comparable with the EN group. In conclusion, the results from this study show that an ongoingW. bancrofti infection induces distinct Breg and Treg populations in peripheral blood from Ghanaian volunteers. Those regulatory immune cell populations might contribute to the regulated state of the host immune system and are probably important for the survival and fertility (microfilaria release) of the helminth.
Description: An article published by PLoSNegl Trop Dis and also available at PLoSNegl Trop Dis PLoSNegl Trop Dis
URI: http://hdl.handle.net/123456789/12718
Appears in Collections:College of Science

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