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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12586

Title: Antimicrobial and antioxidant properties of the crude peptide extracts of galatea paradoxa and patella rustica
Authors: Borquaye, Lawrence Sheringham
Darko, Godfred
Ocansey, Edward
Ankomah, Emmanuel
Keywords: Bacteria
Fungi
Bioactive compounds
Marine molluscs
Freshwater molluscs
Issue Date: 17-Sep-2015
Publisher: SpringerPlus
Citation: Borquaye et al. SpringerPlus (2015) 4:500, Antimicrobial and antioxidant properties of the crude peptide extracts of galatea paradoxa and patella rustica, DOI 10.1186/s40064-015-1266-2
Abstract: This study evaluated the antimicrobial and antioxidant activities of crude peptide extracted from Galatea paradoxa (G. paradoxa) and Patella rustica (P. rustica). The extracts were tested against eight strains of bacteria (Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Salmonella typhi, Enterococcus feacalis, Klebseilla pneumoniae, Streptococcus pneumoniae, Pseudomonas aeruginosa) and one strain of fungi (Candida albicans) using agar well diffusion and broth dilution assays. The extracts from G. paradoxa demonstrated a high degree of activity against the bacteria strains but were inactive towards the fungus. P. rustica, however, showed a markedly higher antifungal activity but little antibacterial effect. The minimum inhibitory concentrations (MIC) of the extracts determined by the broth tube dilution assay were 17 mg/mL of G. paradoxa against the entire spectrum of microorganisms tested except for C. albicans which was 20 mg/mL. The MIC of the extracts of P. rustica was 13 mg/mL against all the strains of microorganisms tested except for E. feacalis (17 mg/mL), K. pneumoniae (17 mg/mL) and C. albicans (13 mg/mL). Antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay showed scavenging ability on the DPPH radical was 56.77 % at 0.39 mg/ mL for G. paradoxa and 79.77 % at 0.39 mg/mL for P. rustica. The study indicates that the crude peptide extracts from the two molluscs have promising antimicrobial and antioxidant activities that can be harnessed as leads for potential bioactive compounds.
Description: An article published by SpringerPlus and also available at DOI 10.1186/s40064-015-1266-2
URI: http://hdl.handle.net/123456789/12586
Appears in Collections:College of Science

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