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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12577

Title: Anti-inflammatory and anti-oxidant activities of ethanolic extracts of tamarindus indica L. (fabaceae)
Authors: Borquaye, Lawrence Sheringham
Doetse, Michel Selassie
Baah, Samuel Ofori
Mensah, Jennifer Amo
Keywords: herbal plant validation
carrageenan-induced paw edema
total antioxidant capacity
phosphomolybdenum assay
Issue Date: 27-Mar-2020
Publisher: Cogent Chemistry
Citation: Lawrence Sheringham Borquaye, Michel Selassie Doetse, Samuel Ofori Baah & Jennifer Amo Mensah | (2020) Anti-inflammatory and anti-oxidant activities of ethanolic extracts of Tamarindus indica L. (Fabaceae), Cogent Chemistry, 6:1, 1743403
Abstract: Various parts of Tamarindus indica L are used to treat inflammatory disorders. This study evaluated the anti-inflammatory and antioxidant activities of the ethanolic extracts of the root and stem bark of the plant. The carrageenan-induced paw edema model of inflammation in chicks was used to assess anti-inflammatory activity. The phosphomolybdenum (PM) assay, 2, 2—diphenyl—1—picrylhydrazyl (DPPH) radical and hydrogen peroxide scavenging assays were used to investigate antioxidant potential. Total phenolic content was evaluated by the Folin–Ciocalteu method. Both stem bark and root extracts possessed similar total phenolic content (11–13 g/100 g AAE) and had comparable total antioxidant capacities (about 27 g/ 100 g GAE). However, the stem bark extract was a better scavenger of both DPPH radicals and hydrogen peroxide, with lower IC50 values than the root extract. In the anti-inflammation test, both extracts exhibited dose-dependent reduction of edema, similar to the standard drugs used. The root extract, with ED50 of 118.1 ± 1.9 mg/kg, proved superior to the stem bark extract, whose ED50 was 154.5 ± 2.6 mg/kg. The results showed that both stem bark and root extracts possess potent antiinflammatory and anti-oxidant activity and confirm their use in folkloric medicine.
Description: An article published by Cogent Chemistry and also available at doi.org/10.1080/23312009.2020.1743403
URI: http://hdl.handle.net/123456789/12577
Appears in Collections:College of Science

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