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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12540

Title: Human coronaviruses associated with upper respiratory tract infections in three rural areas of Ghana
Authors: Owusu, Michael
Sylverken, Augustina Angelina
Corman, Victor Max
Larbi, Richard
Anti, Priscilla
et. al
Issue Date: 31-Jul-2014
Publisher: PLOS ONE
Citation: Owusu M, Annan A, Corman VM, Larbi R, Anti P, et al. (2014) Human Coronaviruses Associated with Upper Respiratory Tract Infections in Three Rural Areas of Ghana. PLoS ONE 9(7): e99782. doi:10.1371/journal.pone.0099782
Abstract: Background: Acute respiratory tract infections (ARI) are the leading cause of morbidity and mortality in developing countries, especially in Africa. This study sought to determine whether human coronaviruses (HCoVs) are associated with upper respiratory tract infections among older children and adults in Ghana. Methods: We conducted a case control study among older children and adults in three rural areas of Ghana using asymptomatic subjects as controls. Nasal/Nasopharyngeal swabs were tested for Middle East respiratory syndrome coronavirus (MERS-CoV), HCoV-22E, HCoV-OC43, HCoV-NL63 and HCoV-HKU1 using Reverse Transcriptase Real-Time Polymerase Chain Reaction. Results: Out of 1,213 subjects recruited, 150 (12.4%) were positive for one or more viruses. Of these, single virus detections occurred in 146 subjects (12.0%) and multiple detections occurred in 4 (0.3%). Compared with control subjects, infections with HCoV-229E (OR = 5.15, 95%CI = 2.24–11.78), HCoV-OC43 (OR = 6.16, 95%CI = 1.77–21.65) and combine HCoVs (OR = 2.36, 95%CI = 1.5 = 3.72) were associated with upper respiratory tract infections. HCoVs were found to be seasonally dependent with significant detections in the harmattan season (mainly HCoV-229E) and wet season (mainly HCoV-NL63). A comparison of the obtained sequences resulted in no differences to sequences already published in GenBank. Conclusion: HCoVs could play significant role in causing upper respiratory tract infections among adults and older children in rural areas of Ghana.
Description: An article published by PLOS ONE and also available at doi:10.1371/journal.pone.0099782
URI: http://hdl.handle.net/123456789/12540
Appears in Collections:College of Science

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