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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12530

Title: The effect of alpha (+) -thalassaemia on P. falciparum malaria parasitaemia in children attending Komfo Anokye Teaching Hospital
Authors: Franklin, K.
Opoku-Okrah, C.
Obiri-Danso, K.
Owiredu, W.K.B.A.
Sylverken, Augustina Angelina
Keywords: alpha+thalassaemia
malaria
RBC
microcytosis
Ghana
Issue Date: 2011
Publisher: International Journal of Biomedical Laboratory Science
Citation: International Journal of Biomedical Laboratory Science (IJBLS) 2011 Vo1 1:7-14
Abstract: Malaria reportedly accounts for 10% of Africa’s disease burden and about 90% of the global morbidity and mortality affecting mostly children under 5 years old. Previous studies have ex-pressed varied opinion on the protection from severe Plasmodium falciparum malaria by α+-thalassaemia. A random cross-sectional sampling of 456 children at the Komfo Anokye Teach-ing Hospital (KATH), Kumasi, Ghana were tested for malaria parasite, complete blood count (CBC), serum ferritin, and α-globin genotype. Alpha (+)-thalassaemic children recorded a sig-nificantly lower (28,705/μL) mean parasite density (MPD) compared to non-α-thalassaemic children (35,483/μL) (p<0.0001). The homozygotes, α+-thalassaemia, recorded a significantly lower (691/μL) MPD compared to 26,350/μL for the heterozygotes and 35,483/μL for the non-α-thalassaemic children (p = 0.0001). Alpha (+)-thalassaemia was hypothesized to protect against malaria via a reduction in the parasite density. The homozygous α+-thalassaemias were more protective than the heterozygous. Microcytic hypochromic anaemia was found in 141 (59%) of the subjects of which 71 were α+-thalassaemia. Alpha (+)-thalassaemia was shown to be a possibly key contributor to microcytic hypochromic anaemia amongst cases that were suspected of iron deficiency. Suspected iron deficiency cases should therefore be screened for α-thalassaemia to avoid the unnecessary administration of iron supplement.
Description: An article published by International Journal of Biomedical Laboratory Science
URI: http://hdl.handle.net/123456789/12530
Appears in Collections:College of Science

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