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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12493

Title: Potential Intermediate Hosts for Coronavirus Transmission: No Evidence of Clade 2c Coronaviruses in Domestic Livestock from Ghana
Authors: El-Duah, Philip
Sylverken, A. A
Owusu, Michael
Yeboah, Richmond
Lamptey, Jones
Keywords: livestock
coronavirus
intermediate host
bats
Issue Date: Feb-2019
Publisher: Tropical medicine and infectious disease
Citation: Tropical medicine and infectious disease
Abstract: The emergence of Middle East Respiratory Syndrome Coronavirus (MERS-CoV), nearly a decade ago with worldwide distribution, was believed to be of zoonotic origin from bats with dromedary camels as intermediate hosts. There is a likelihood of other domestic livestock serving as intermediate hosts for this virus. The presence of coronaviruses, closely related to MERS-CoV in Ghanaian bats, presented the opportunity to test the hypothesis of transmissibility of this virus through domestic livestock species. The possible interactions between livestock and bats in 31 household farms were accessed by observation and interviews with farmers. Rectal swabs and serum from cattle, sheep, goats, donkeys, and swine from commercial and household farms were tested for MERS-CoV and a Nycteris sp. bat coronavirus, previously detected in Ghana. A pan-PCR assay to detect clade 2c viruses and recombinant immunofluorescence assay to detect anti-spike IgG antibodies against the target viruses were used. Likely contact between livestock and bats was determined for 13 farms (41.9%) that reported confining their livestock and also observing bats in their homes. Livestock were left unconfined on eight farms (25.8%) that also observed bats roosting in trees close to their homes. No viral RNA or antibodies against the two coronaviruses were detected in any of the livestock species tested. Cattle, sheep, goats, donkeys, and swine are not likely hosts of clade 2c coronaviruses.
Description: This article is published in Tropical and infectious diseases and also available at DOI: 10.3390/tropicalmed4010034
URI: 10.3390/tropicalmed4010034
http://hdl.handle.net/123456789/12493
Appears in Collections:College of Science

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