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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12489

Title: Intestinal Parasitemia and HIV/AIDS Co-infections at Varying CD4+ T-cell Levels
Authors: Tay, Samuel CK
Aryee, Eric Nii Okai
Badu, Kingsley
Keywords: HIV/AIDS
Intestinal parasites
CD4+ T-cell count
Issue Date: 13-Dec-2017
Publisher: Open Journal
Citation: Tay SCK, Aryee ENO, Badu K. Intestinal parasitemia and HIV/AIDS co-infections at varying CD4+ T-cell levels. HIV/ AIDS Res Treat Open J. 2017; 4(1): 40- 48. doi: 10.17140/HARTOJ-4-126
Abstract: Background: Intestinal parasites, especially coccidian parasites, cause gastrointestinal symptoms such as severe diarrhoea which increases morbidity and mortality rates in people living with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS), particularly in Sub-Saharan Africa. We examined the prevalence of intestinal parasites in people living with AIDS at different CD4+ T-cell levels. Method: Case-control studies were conducted over a four month period including a total of 672 participants, between the ages of 8 and 72 years. HIV screening and confirmatory tests were done. We examined stool samples by wet mount, followed by formol-ether concentration and staining with Modified Field’s and Ziehl Neelsen techniques. We also carried out fluorescenceactivated cell sorting (FACS) analyses to obtain their CD4+ T-cell levels. Results: The prevalence of intestinal parasites were significantly higher (25.2%) among HIV seropositives than HIV seronegative individuals (13.3%), (p<0.001). Coccidian parasites: Cystoisospora belli (formerly Isospora belli), Cryptosporidium and the round worm Strongyloides stercoralis infections were found exclusively in HIV seropositives. Cryptosporidium infections were more frequently observed in the rural cohort (p=0.039). C. belli, Cryptosporidium, Giardia lamblia and Strongyloides stercoralis infections were significantly higher in diarrhoeic stools. Microsporidia and Cystoisospora belli were found mostly in individuals with CD4+ T-cell levels of ≤200 cells/μL. Participants with CD4+ T-cell count of ≤50 cells/μL were associated with diarrhoea. Conclusion: The prevalence of opportunistic coccidian parasites remains high in HIV-infected individuals with low CD4+ T-cell counts. Routine diagnosis is recommended to ensure comprehensive care for HIV patients.
Description: An article published by Open Journal and also available at http://dx.doi.org/10.17140/HARTOJ-4-126
URI: http://hdl.handle.net/123456789/12489
Appears in Collections:College of Science

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