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|Title: ||Sex and site differences in urinary excretion of conjugated pyrene metabolites in the West African Shorthorn cattle|
|Authors: ||BORTEY-SAM, Nesta|
NAKAYAMA, Shouta M.M.
MARFO, Jemima T.
|Issue Date: ||Dec-2017|
|Publisher: ||The journal of veterinary medical sciences|
|Citation: ||The journal of veterinary medical sciences|
|Abstract: ||Industrialization, economic and population growth rates in Ghana have increased
the release of contaminants including polycyclic aromatic hydrocarbons (PAHs) into the
environment through which humans and animals are exposed. Cattle is reported to be exposed
to high levels of PAHs through feed and inhalation. Once exposed, PAHs are metabolized and
excreted in urine, feces or bile. In a previous study, cattle in Ghana was reported to excrete high
levels of 1-hydroxypyrene (1-OHPyr) due to high exposure to the parent compound, pyrene.
1-OHPyr is further metabolized to glucuronide and sulfate conjugates. Thus, the aim of this
study was to investigate the sex and site differences in urinary excretion of conjugated pyrene
metabolites using cattle urine collected from rural and urban sites of the Ashanti region, Ghana.
From the results, geometric mean concentration adjusted by specific gravity indicated that
1-OHPyreneGlucuronide (PyG) was the most abundant conjugate followed by PyrenediolSulfate
(M3). The sum of conjugated pyrene metabolites and sum of both conjugated and deconjugated
pyrene metabolites correlated significantly with PyG, PydiolSulfate (M2) and PydiolSulfate (M3).
The study revealed no significant difference in urinary excretion of conjugated pyrene metabolites
between rural and urban sites. This indicated that similar to urban sites, cattle in rural sites were
exposed to high levels of pyrene. There was no significant difference in urinary concentrations of
conjugated pyrene metabolites between sexes.|
|Description: ||This article is published in The journal of veterinary medical sciences and also available at doi: 10.1292/jvms.17-0410|
|Appears in Collections:||College of Science|
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