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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12368

Title: Oxidative stress and respiratory symptoms due to human exposure to polycyclic aromatic hydrocarbons (PAHs) in Kumasi, Ghana
Authors: Bortey-Sam, Nesta
Ikenaka, Yoshinori
Akoto, Osei
Nakayama, Shouta M.M.
Asante, Kwadwo A.
Baidoo, Elvis
Obirikorang, Christian
Saengtienchai, Aksorn
Isoda, Norikazu
Nimako, Collins
Mizukawa, Hazuki
Ishizuka, Mayumi
Keywords: OH-PAHs
Issue Date: May-2017
Publisher: Environmental Pollution
Citation: Environmental Pollution
Abstract: Studies of polycyclic aromatic hydrocarbons (PAHs) and its metabolites in PM10, soils, rat livers and cattle urine in Kumasi, Ghana, revealed high concentrations and cancer potency. In addition, WHO and IARC have reported an increase in cancer incidence and respiratory diseases in Ghana. Human urine were therefore collected from urban and control sites to: assess the health effects associated with PAHs exposure using malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OHdG); identify any association between OH-PAHs, MDA, 8-OHdG with age and sex; and determine the relationship between PAHs exposure and occurrence of respiratory diseases. From the results, urinary concentrations of the sum of OH-PAHs (POHPAHs) were significantly higher from urban sites compared to the control site. Geometric mean concentrations adjusted by specific gravity, GMSG, indicated 2-OHNaphthalene (2- OHNap) (6.01 ± 4.21 ng/mL) as the most abundant OH-PAH, and exposure could be through the use of naphthalene-containing-mothballs in drinking water purification, insect repellent, freshener in clothes and/or “treatment of various ailments”. The study revealed that exposure to naphthalene significantly increases the occurrence of persistent cough (OR ¼ 2.68, CI: 1.43e5.05), persistent headache (OR ¼ 1.82, CI: 1.02e3.26), tachycardia (OR ¼ 3.36, CI: 1.39e8.10) and dyspnea (OR ¼ 3.07, CI: 1.27e7.43) in Kumasi residents. Highest level of urinary 2-OHNap (224 ng/mL) was detected in a female, who reported symptoms of persistent cough, headache, tachycardia, nasal congestion and inflammation, all of which are symptoms of naphthalene exposure according to USEPA. The POHPAHs, 2-OHNap, 2-3-OHFluorenes, and -OHPhenanthrenes showed a significantly positive correlation with MDA and 4-OHPhenanthrene with 8-OHdG, indicating possible lipid peroxidation/cell damage or degenerative disease in some participants. MDA and 8-OHdG were highest in age group 21e60. The present study showed a significant sex difference with higher levels of urinary OH-PAHs in females than males.
Description: This article is published in Environmental Pollution and also available at (M. Ishizuka). Contents lists available at ScienceDirect Environmental Pollution http://dx.doi.org/10.1016/j.envpol.2017.05.036
URI: 10.1016/j.envpol.2017.05.036
Appears in Collections:College of Science

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