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|Title: ||Safety Evaluation of BF001, an Anti-diabetic Herbal Preparation in Sprague-Dawley Rats|
|Authors: ||Owiredu, W.K.B.A.|
|Issue Date: ||13-Mar-2011|
|Publisher: ||West African Journal of Pharmacy|
|Citation: ||West African Journal of Pharmacy (2011) 22 (1) 49 - 57|
|Abstract: ||Background: "BF001" is a herbal preparation made from the leaves of Bridelia ferruginea. Despite its prolonged
use in treating diabetes mellitus, there is no empirical evidence of its safety as a hypoglycaemic agent.
Objectives: This study evaluated the acute and chronic toxicity of 'BF001' with the view to determining the LD50
and toxic effects on specific organs after prolonged administration in male Spraque-Dawley rats.
-1 Methods: Acute toxicity was carried out within 14 days; a single high dose of 5000 mg kg body weight was
administered orally to a group of 8 rats to determine LD . Chronic toxicity was also carried out over a period of 6 50
-1 -1 months (180 days) at the normal therapeutic dose level (41 mg kg ) and ten times the normal dose (410 mg kg ).
Results: There were no significant differences found in most of the haematological, urine chemistry, serum
biochemical parameters and relative organ weight. It, however, caused a significant decrease in pentobarbitone
-1 induced sleeping time. The oral LD of 'BF001' is above 5000 mg kg body weight. 50
Conclusion: 'BF001' had no overt organ specific toxicity but may modulate the production and/or the activity of
certain microsomal monooxygenases which may lead to drug-drug interactions if the test preparation is taken
concurrently with other medicinal preparations.|
|Description: ||An article published by West African Journal of Pharmacy|
|Appears in Collections:||College of Health Sciences|
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