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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12364

Title: Diferential expression pattern of co-inhibitory molecules on CD4+ T cells in uncomplicated versus complicated malaria
Authors: Abe, Annemieke
Steeg, Christiane
Aminkiah, Francis
Addai-Mensah, Otchere
Marylyn Addo
et. al
Issue Date: 19-Mar-2018
Publisher: AMER SOC TROP MED & HYGIENE
Citation: SCientifiC Reports | (2018) 8:4789 | DOI:10.1038/s41598-018-22659-1
Abstract: The immune response of malaria patients is a main factor infuencing the clinical severity of malaria. A tight regulation of the CD4+ T cell response or the induction of tolerance have been proposed to contribute to protection from severe or clinical disease. We therefore compared the CD4+ T cell phenotypes of Ghanaian children with complicated malaria, uncomplicated malaria, asymptomatic Plasmodium falciparum (Pf) infection or no infection. Using fow cytometric analysis and automated multivariate clustering, we characterized the expression of the co-inhibitory molecules CTLA-4, PD-1, Tim-3, and LAG-3 and other molecules implicated in regulatory function on CD4+ T cells. Children with complicated malaria had higher frequencies of CTLA-4+ or PD-1+ CD4+ T cells than children with uncomplicated malaria. Conversely, children with uncomplicated malaria showed a higher proportion of CD4+ T cells expressing CD39 and Granzyme B, compared to children with complicated malaria. In contrast, asymptomatically infected children expressed only low levels of co-inhibitory molecules. Thus, diferent CD4+ T cell phenotypes are associated with complicated versus uncomplicated malaria, suggesting a two-sided role of CD4+ T cells in malaria pathogenesis and protection. Deciphering the signals that shape the CD4+ T cell phenotype in malaria will be important for new treatment and immunization strategies.
Description: An article published by AMER SOC TROP MED & HYGIENE and also available at DOI:10.1038/s41598-018-22659-1
URI: http://hdl.handle.net/123456789/12364
Appears in Collections:College of Health Sciences

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