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|Title: ||Establishment of a phage display platform for the isolation of Plasmodium falciparum specific monoclonal antibodies|
|Authors: ||Addai-Mensah, Otchere|
|Issue Date: ||2015|
|Publisher: ||Fachgruppe Biologie|
|Abstract: ||PREVALENCE, SEVERITY AND IMPACT ON WORLD HEALTH
Malaria is an important cause of morbidity and mortality, particularly in sub-Saharan Africa where it accounts for between 300-500 million infections per year with 1.5-2.7 million deaths, with more than 90% of the deaths occurring in children under the age of 5 . More than 90% of these deaths occur on the continent of Africa, and are due to Plasmodium falciparum, one of the five main species of plasmodium that infects man . Infected female anopheles mosquitoes transmit the parasite when they bite to take a blood meal. Latest estimates suggest that malaria kills more people than HIV .
In many developing countries and in Africa especially, malaria exacts an enormous toll on life, not only in medical costs, but also in days of labour lost. The goal of producing an effective malaria vaccine still remains elusive, several years after the cloning of the malaria genes due in part to the multistage life cycle of the parasite, each with stage specific antigens, and the genetic diversity of the Plasmodium falciparum parasite, coupled with the poor understanding of the complex nature of the immune response to the parasite .
Despite intense research, either to eradicate malaria or lessen its fatality and morbidity, an effective control strategy still remains to be achieved. The development of resistance to cheap and previously reliable drugs like chloroquine by the Plasmodium parasites, particularly falciparum require that new therapeutic measures be developed if the fight against the disease is to be won.|
|Description: ||An article published by Fachgruppe Biologie|
|Appears in Collections:||College of Health Sciences|
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