Research Articles >
College of Health Sciences >
Please use this identifier to cite or link to this item:
|Title: ||In vitro anti-plasmodial activity of three herbal remedies for malaria in Ghana: Adenia cissampeloides (Planch.) Harms., Termina liaivorensis A. Chev, and Elaeis guineensis Jacq|
|Authors: ||Annan, Kofi|
Dickson, Rita A.
|Keywords: ||Adenia cissampeloides|
|Issue Date: ||Oct-2012|
|Publisher: ||Pharmacognosy Research|
|Citation: ||Pharmacognosy Research, | Vol 4 | Issue 4|
|Abstract: ||Background: Herbal remedies of Adenia cissampeloides, Terminalia ivorensis, and Elaeis
guineensis among others have been used in Ghana for the treatment of various ailments
including malaria. However, most of these remedies have not been scientifically investigated.
Objective: This study, therefore, seeks to investigate the anti-plasmodial activity of these
plants. Materials and Methods: The ethanolic extracts of A. cissampeloides stem, T. ivorensis
stem bark, and E. guineensis leaves were tested for in vitro anti-plasmodial activity against
chloroquine-resistant strains of Plasmodium falciparum. Thin blood films were used to assess the
level of parasitemia and growth inhibition of the extracts. Results: The IC50 of A. cissampeloides,
T. ivorensis, and E. guineensis were 8.521, 6.949, and 1.195 µg/ml, respectively, compared
to artesunate with IC50 of 0.031 µg/ml. Conclusion: The result of this study appears to confirm
the folkloric anti-malarial use these plants.
Key words: Adenia cissampelo|
|Description: ||This article is published in Pharmacognosy Research and also available at DOI:
|URI: ||DOI: 10.4103/0974-8490.102270|
|Appears in Collections:||College of Health Sciences|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.