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|Title: ||ANTIDIABETIC AND HAEMATOLOGICAL EFFECT OF MYRIANTHUS ARBOREUS P. BEAUV. STEM BARK EXTRACT IN STREPTOZOTOCIN - INDUCED DIABETIC RATS|
|Authors: ||Dickson, Rita A.|
Harley, B. K.
Ngala, R. A.
|Issue Date: ||Dec-2016|
|Publisher: ||International Journal of Pharmaceutical Sciences and Research|
|Citation: ||International Journal of Pharmaceutical Sciences and Research, Vol. 7(12): 4812-4826.|
|Abstract: ||ABSTRACT: The increasing prevalence of diabetes mellitus worldwide is an
issue of major socio-economic concern especially in Sub - Saharan Africa.
Indigenous medicinal plants are used for the treatment of diabetes mellitus in
most developing countries, like Ghana, but remain to be validated. In the present
study, the effect of Myrianthus arboreus ethanol stem bark extract (MAB) (100 -
400 mg/kg) on glucose levels in streptozotocin (STZ) (45 mg/kg) induced
diabetic rats was investigated using glibenclamide 5 mg/kg/day as the positive
control. The effects of the extract on body weight, total protein, serum urea,
serum creatinine, bilirubin, lipid profile, haematological indices and serum
markers for liver function in normal, treated and untreated diabetic rats were also
investigated. Induction of the diabetes in Sprague Dawley rats (150-200 g)
resulted in increased levels of serum glucose, total cholesterol, triglycerides and
LDL-cholesterol but decreased body weight, serum HDL-cholesterol and
haemoglobin levels. Administration of the extract at the three dose levels
resulted in significant (P<0.001) reduction in the levels of plasma glucose,
cholesterol, LDL-cholesterol, triglycerides and serum urea and serum creatinine.
Alanine transaminase (ALT) and aspartate transaminase (AST) levels were also
significantly (P<0.001) decreased. The significant decrease in body weight, total
protein and HDL-cholesterol which were observed in STZ-induced diabetic rats
were normalized after 28 days treatment with the extract. At 200 mg/kg/day,
MAB recorded significant (P<0.01) reduction in plasma glucose levels
compared to glibenclamide (5 m/kg/day). Thus MAB shows significant
hypoglycaemic and antihyperlipidaemic activities in STZ-induced diabetic rats
justifying its use in traditional medicine|
|Description: ||This article is published in International Journal of Pharmaceutical Sciences and Research and also available at DOI link: http://dx.doi.org/10.13040/IJPSR.0975-8232.7 (12).4812-26|
|URI: ||10.13040/IJPSR.0975-8232.7 (12).4812-26|
|Appears in Collections:||College of Health Sciences|
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