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|Title: ||A RANDOMIZED, DOUBLE-BLIND STUDY EVALUATING THE SAFETY AND EFFECTIVENESS OF A GHANAIAN POLYHERBAL PRODUCT FOR THE MANAGEMENT OF SUPERFICIAL MYCOSES|
|Authors: ||Thomford, K.P.|
Dickson, Rita A.
Sarfo, B.S. D.
|Keywords: ||Herbal medicine|
Randomised double blind parallel controlled study
|Issue Date: ||Jun-2015|
|Publisher: ||Herbal Medicine|
|Citation: ||Herbal Medicine,|
|Abstract: ||A prospective randomised double blind parallel controlled trial was conducted to evaluate the
safety and clinical effectiveness of a standardised Ghanaian polyherbal product EAF-2011
comprising; Alchornea cordifolia, Eugenia caryophyllata, Psidium guajava, Tridax
procumbens and Zanthoxylum zanthoxyloides, used in the management of skin diseases.
A total number of 84 participants aged between 8 and 45 years who were clinically diagnosed
with superficial mycoses were recruited into the study and followed up for 4 months.
Participants were randomised to receive 2%, 5% or 10% (w
/w) concentrations of the finished
herbal product or the control treatment of Whitfield ointment. Primary efficacy outcome
(complete cure): defined as Total Signs and Symptoms Score (TSSS) of zero and where
applicable mycological cure also defined as a negative mycological culture and microscopic
examination was achieved by 30.0%, 34.78%, 75.0% and 91.30% of the control, 2%, 5% and
/w) EAF-2011 treatments respectively. Safety analyses using urine, biochemical and
haematological parameters were normal at the end of the study. Also, no adverse reactions
were recorded during the study. The study thus showed all the treatments to be safe and
effective for the management of dermatophytes with 10% (
/w) finished herbal product being
the most effective treatment.|
|Description: ||This article is published in Herbal Medicine and also available at DOI: http://dx.doi.org/doi:10.1016/j.hermed.2015.06.001|
|URI: ||DOI: http://dx.doi.org/doi:10.1016/j.hermed.2015.06.001|
|Appears in Collections:||College of Health Sciences|
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