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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12070

Title: Flavonoid glycosides from the stem bark of Margaritaria discoidea demonstrate antibacterial and free radical scavenging activities
Authors: Ekuadz, Edmund
Dickson, Rita A.
Fleischer, Theophilus
Annan, Kofi
Pistorius, Dominik
Oberer, Lukas
Gibbons, Simon
Keywords: Margaritaria discoidea
; flavonoid glycosides
margadiscoside
fagovatin
antibacterial activities
antioxidant activities
Issue Date: Aug-2013
Publisher: PHYTOTHERAPY RESEARCH
Citation: PHYTOTHERAPY RESEARCH, . 28: 784–787 (2014)
Abstract: One new flavonoid glycoside, along with three known flavonoid glycosides were isolated from the stem bark of Margaritaria discoidea, which is traditionally used in the management of wounds and skin infections in Ghana. The new flavonoid glycoside was elucidated as hydroxygenkwanin‐8‐C‐[α‐rhamnopyranosyl‐(1 → 6)]‐β‐glucopyranoside (1) on the basis of spectroscopic analysis. The isolated compounds demonstrated free‐radical scavenging as well as some level of antibacterial activities. Microorganisms including Staphylococcus aureus are implicated in inhibiting or delaying wound healing. Therefore, any agent capable of reducing or eliminating the microbial load present in a wound as well as decreasing the levels of reactive oxygen species may facilitate the healing process. These findings therefore provide some support to the ethnopharmacological usage of the plant in the management of wounds. Copyright © 2013 John Wiley & Sons, Ltd.
Description: This article is published in PHYTOTHERAPY RESEARCH and also available at DOI: 10.1002/ptr.5053
URI: 10.1002/ptr.5053
http://hdl.handle.net/123456789/12070
Appears in Collections:College of Health Sciences

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