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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12021

Title: Epidemiology of Mansonella perstans in the middle belt of Ghana
Authors: A. Y, Debrah
Debrah, Linda Batsa
Nausch, Norman
Opoku, Vera Serwaa
Owusu, Wellington
Mubarik, Yusif
Berko, Daniel Antwi
Wanji, Samuel
Layland, Laura E.
Hoerauf, Achim
Jacobsen, Marc
Phillips, Richard O.
Keywords: Mansonellosis
Mansonella perstans
Culicoides
Microfilariae
Epidemiology
Issue Date: Dec-2017
Publisher: Parasites & Vectors
Citation: Parasites & Vectors, 10(1)
Abstract: Background: Mansonellosis was first reported in Ghana by Awadzi in the 1990s. Co-infections of Mansonella perstans have also been reported in a small cohort of patients with Buruli ulcer and their contacts. However, no study has assessed the exact prevalence of the disease in a larger study population. This study therefore aimed to find out the prevalence of M. perstans infection in some districts in Ghana and to determine the diversity of Culicoides that could be potential vectors for transmission. Methods: From each participant screened in the Asante Akim North (Ashanti Region), Sene West and Atebubu Amantin (Brong Ahafo Region) districts, a total of 70 μl of finger prick blood was collected for assessment of M. perstans microfilariae. Centre for Disease Control (CDC) light traps as well as the Human Landing Catch (HLC) method were used to assess the species diversity of Culicoides present in the study communities. Results: From 2,247 participants, an overall prevalence of 32% was recorded although up to 75% prevalence was demonstrated in some of the communities. Culicoides inornatipennis was the only species of Culicoides caught with the HLC method. By contrast, C. imicola (47%), C. neavei (25%) and C. schultzei (15%) were caught by the CDC light trap method. A wide diversity of other Culicoides spp. was also identified but correlation was only found between the prevalence of C. inornatipennis and M. perstans during the dry season. Conclusions: Here we demonstrate for the first time that M. perstans is highly prevalent in three districts in Ghana. We found a wide spectrum of Culicoides spp. Culicoides inornatipennis was the most anthropophilic and is therefore likely to be the species responsible for transmission of infection but formal proof has yet to be obtained. Trial registration: NCT02281643 . Registered October 26, 2014. 'Retrospectively registered'. Trial registry: ClinicalTrials.gov.
Description: This article is published in Parasites & Vectors and also available at DOI: 10.1186/s13071-016-1960-0
URI: 10.1186/s13071-016-1960-0
http://hdl.handle.net/123456789/12021
Appears in Collections:College of Health Sciences

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