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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/11973

Title: Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial
Authors: Klarmann-Schulz, Ute
Specht, Sabine
Debrah, A. Y
Batsa, Linda
Ayisi-Boateng, Nana Kwame
Osei-Mensah, Jubin
Mubarik, Yusif
Konadu, Peter
Ricchiuto, Arcangelo
Fimmers, Rolf
Arriens, Sandra
Dubben, Bettina
For, Louise
Taylor, Mark
Hoerauf, Achim
Issue Date: Jan-2017
Publisher: PLoS Neglected Tropical Diseases
Citation: PLoS Neglected Tropical Diseases 11(1):e0005156
Abstract: The search for new macrofilaricidal drugs against onchocerciasis that can be administered in shorter regimens than required for doxycycline (DOX, 200mg/d given for 4–6 weeks), identified minocycline (MIN) with superior efficacy to DOX. Further reduction in the treatment regimen may be achieved with co-administration with standard anti-filarial drugs. Therefore a randomized, open-label, pilot trial was carried out in an area in Ghana endemic for onchocerciasis, comprising 5 different regimens: the standard regimen DOX 200mg/d for 4 weeks (DOX 4w, N = 33), the experimental regimens MIN 200mg/d for 3 weeks (MIN 3w; N = 30), DOX 200mg/d for 3 weeks plus albendazole (ALB) 800mg/d for 3 days (DOX 3w + ALB 3d, N = 32), DOX 200mg/d for 3 weeks (DOX 3w, N = 31) and ALB 800mg for 3 days (ALB 3d, N = 30). Out of 158 randomized participants, 116 (74.4%) were present for the follow-up at 6 months of whom 99 participants (63.5%) followed the treatment per protocol and underwent surgery. Histological analysis of the adult worms in the extirpated nodules revealed absence of Wolbachia in 98.8% (DOX 4w), 81.4% (DOX 3w + ALB 3d), 72.7% (MIN 3w), 64.1% (DOX 3w) and 35.2% (ALB 3d) of the female worms. All 4 treatment regimens showed superiority to ALB 3d (p < 0.001, p < 0.001, p = 0.002, p = 0.008, respectively), which was confirmed by real-time PCR. Additionally, DOX 4w showed superiority to all other treatment arms. Furthermore DOX 4w and DOX 3w + ALB 3d showed a higher amount of female worms with degenerated embryogenesis compared to ALB 3d (p = 0.028,
Description: This article has been published in PLoS Neglected Tropical Diseases and also available at DOI: 10.1371/journal.pntd.0005156
URI: 10.1371/journal.pntd.0005156
http://hdl.handle.net/123456789/11973
Appears in Collections:College of Health Sciences

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Comparison-of-Doxycycline-Minocycline-Doxycycline-plus-Albendazole-and-Albendazole-Alone-in-Their-Efficacy-against-Onchocerciasis-in-a-Randomized-OpenLabel-Pilot-Trial2017PLoS-Neglected-Tropical-DiseasesOpen-Access.pdf3.16 MBAdobe PDFView/Open

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