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|Title: ||Spectrum of disease in HIV-positive patients presenting to a tertiary care hospital: a retrospective, cross-sectional review in Kumasi, Ghana|
|Authors: ||Phillips, Richard O.|
|Issue Date: ||23-Aug-2018|
|Publisher: ||BMC Infect Dis|
|Citation: ||BMC Infect Dis 18, 419 (2018) doi:10.1186/s12879-018-3332-1|
|Abstract: ||Background: HIV remains a significant public health dilemma in West and Central Africa. HIV-related morbidity and
mortality are unjustly high, yet little is known about the spectrum of complicating comorbidities in HIV-positive
patients who are admitted to hospitals in these regions.
Methods: This study involved a retrospective chart review to determine the common comorbidities and mortality
rate of HIV-infected patients admitted over a six month period to the internal medicine service at the Komfo Anokye
Teaching Hospital (KATH), a tertiary care center in Ghana. Patients admitted with a known or new HIV diagnosis from
January to July 2016 were included. Data were collected regarding the number of new versus known cases admitted,
the most common presenting complaints, final admitting diagnoses, and causes of mortality in these patients.
Results: During the six-month study period, 250 HIV-positive patients were admitted to KATH, and 245 of these
individuals had valid survival time recorded. Of these patients, 145/245 (59.2%) were female. Median age of patients
included in the study was 42 years old (IQR 35–51). The mortality rate for HIV patients admitted to the hospital was 35.
5% (87 patients). One hundred and forty-five (59.4%) patients had a known history of HIV documented in their patient
charts, while the remaining patients were newly diagnosed with HIV during their inpatient stay. Pulmonary tuberculosis
predominated among diagnostic findings, with 40.4% of HIV-infected patients diagnosed with the condition while
admitted. Patients presenting with neurological symptoms on admission were 2.14 (95% CI: 1.27–3.61) times more
likely to die than those without neurological symptoms (p = .004).
Conclusions: Over 40% of HIV-positive patients admitted to KATH were newly diagnosed with HIV at admission. While
pulmonary tuberculosis was the most common co-morbidity, patients presenting with neurological symptoms were at
higher risk of death. This study suggests that enhanced outpatient screening is needed for early diagnosis and prompt
HAART initiation, as well as increased access to diagnostic modalities and treatment for HIV-positive patients with
|Description: ||An article published by BMC Infectious Diseases and available at doi.org/10.1186/s12879-018-3332-1|
|Appears in Collections:||College of Health Sciences|
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