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|Title: ||Assessment of Wound-Healing Properties of Medicinal Plants: The Case of Phyllanthus muellerianus|
|Authors: ||Boakye, Yaw D|
.Ayande, George P
Asiamah, Emmanuel A.
|Issue Date: ||21-Aug-2018|
|Publisher: ||Front. Pharmacol|
|Citation: ||Front. Pharmacol doi.org/10.3389/fphar.2018.00945|
|Abstract: ||Wounds represent a major global health challenge, which put much economic, financial, and social stress on health institutions, care-givers, patients, and their families (Benbow, 2011). Wounds are defined as physical, chemical, or thermal injuries or insult that result in an opening or breaking in the integrity of the skin or the disruption of anatomical and functional integrity of living tissues (Meenakshi et al., 2006).
The use of medicinal plants in the management of acute and chronic wounds is common in most traditional medicine practices in the world. Based on this, many plants in the tropical and subtropical regions of the world have been screened for their wound-healing activity (Agyare et al., 2009; Farzaei et al., 2014). There are a lot of medicinal plants to be screened in the search for newer, efficacious, and cost effective wound-healing agents.
Phyllanthus muellerianus (Kuntze) Exell, which belongs to the family Euphorbiaceae, is widely distributed in West Africa. It is used traditionally in treating wounds in Ghana and other parts of West Africa (Agyare et al., 2009). It is also used to manage menstrual disturbances, pain, dysentery, gonorhoea, and stomach sores. Freshly ground leaves are applied to boils, wounds, and also used for treatment of menstrual disorders, fevers, and skin eruptions in Sierra Leone, Ghana, Nigeria, and Cameroon (Burkill, 2000; Agyare et al., 2009). Fresh leaves and decoction are used to treat constipation, bronchitis, and urethral discharges (Chopra et al., 1986; Siram et al., 2004). The bark of P. muellerianus has been shown to contain 22β-hydroxyfriedel-1-ene, 1β, 22β-hydroxyfriedel-1-ene (Adesida et al., 1972). In addition, geraniin, furosin, corilagin, isoquercitrin, astragalin, rutin, phaselic acid, gallic acid, methylgallate, caffeic acid, chlorogenic acid, 3,5-o-dicaffeoylquinic acid have been isolated from the leaves and aerial parts of P. muellerianus (Agyare et al., 2011). Saleem et al. (2009) also isolated bis (2-ethyloctyl) phthalate, bis (2-ethylicosyl) phthalate, 3-friedelanone, methylgallate, β-sitosterol from the leaves of P. muellerianus.
Agyare et al. (2011) reported that the aqueous leaf extract of P. muellerianus and its major isolate, geraniin stimulate cellular activity, differentiation, and collagen synthesis of human skin keratinocytes and dermal fibroblasts. The anti-infective (Boakye et al., 2016c), anti-inflammatory (Boakye et al., 2016a), and antioxidant activities (Wang et al., 2015; Boakye et al., 2016b) of P. muellerianus and geraniin have also been reported. However, the folkloric use of P. muellerianus as a wound-healing agent has not been scientifically proven in in vivo models. Hence, the aim of the study was to investigate the in vivo wound-healing activity of P. muellerianus and its major metabolite, geraniin.|
|Description: ||An article published by Front. Pharmacol|
|Appears in Collections:||College of Health Sciences|
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