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|Title: ||Helicobacter pylori Coinfection Is Associated With Decreased Markers of Immune Activation in ART-Naive HIV-Positive and in HIV-Negative Individuals in Ghana|
|Authors: ||Phillips, Richard O.|
Eberhardt, Kirsten Alexandra
Sarfo, Fred Stephen
Kuffour, Edmund Osei
|Issue Date: ||15-Nov-2015|
|Publisher: ||Oxford University Press|
|Citation: ||Oxford University Press CID 2015:61 (15 November) • 1615|
|Abstract: ||Background. Helicobacter pylori coinfection in human immunodeficiency virus (HIV) patients has been associated
with higher CD4+ cell counts and lower HIV-1 viral loads, with the underlying mechanisms being unknown.
The objective of this study was to investigate the impact of H. pylori infection on markers of T-cell activation in HIVpositive
and HIV-negative individuals.
Methods. In a cross-sectional, observational study, HIV patients (n = 457) and HIV-negative blood donors
(n = 79) presenting to an HIV clinic in Ghana were enrolled. Data on clinical and sociodemographic parameters,
CD4+/CD8+ T-cell counts, and HIV-1 viral load were recorded. Helicobacter pylori status was tested using a
stool antigen test. Cell surface and intracellular markers related to T-cell immune activation and turnover were quantified
by flow cytometry and compared according to HIV and H. pylori status.
Results. Helicobacter pylori infection was associated with decreased markers of CD4+ T-cell activation (HLADR+
CD38+CD4+; 22.55% vs 32.70%; P = .002), cell proliferation (Ki67; 15.10% vs 26.80%; P = .016), and immune
exhaustion (PD-1; 32.45% vs 40.00%; P = .005) in 243 antiretroviral therapy (ART)–naive patients, but not in 214
patients on ART. In HIV-negative individuals, H. pylori infection was associated with decreased frequencies of activated
CD4+ and CD8+ T cells (6.31% vs 10.40%; P = .014 and 18.70% vs 34.85%, P = .006, respectively).
Conclusions. Our findings suggest that H. pylori coinfection effectuates a systemic immune modulatory effect with
decreased T-cell activation in HIV-positive, ART-naive patients but also in HIV-negative individuals. This findingmight,
in part, explain the observed association of H. pylori infection with favorable parameters of HIV disease progression.
Clinical Trials Registration. Clinicaltrials.gov NCT01897909.|
|Description: ||An article published by Oxford University Press and available at DOI: 10.1093/cid/civ577|
|Appears in Collections:||College of Health Sciences|
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