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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/11887

Title: Long-term responses to first-line antiretroviral therapy in HIV and hepatitis B co-infection in Ghana
Authors: Sarfo, Fred Stephen
Kasim, Adetayo
Phillips, Richard
Geretti, Anna Maria
Chadwick, David R.
Keywords: Hepatitis B
HIV
Clinical outcomes
Lamivudine
Antiretroviral therapy
Issue Date: Jun-2014
Publisher: Elsevier Ltd
Citation: Elsevier Ltd 69, 481-489
Abstract: To observe the long term response to first-line antiretroviral therapy (ART) in HIV and hepatitis B virus (HBV) co-infected patients in Ghana and explore predictors of poor clinical outcomes. Methods: Retrospective cohort study of hepatitis B surface antigen (HBsAg) positive and negative patients receiving predominantly NNRTI-based ART with lamivudine plus either zidovudine or stavudine for up to seven years. Cox proportional hazards and Kaplan Meier survival analyses compared clinical outcomes and identified baseline characteristics predictive of poor outcomes. A mixed effects model compared changes in CD4 counts. Results: A total of 299 HBsAg-positive and 1869 HBsAg-negative patients started ART between 2004 and 2008. Over a median 35 months of follow-up, HBsAg-positive patients were more likely to die or default care than HBsAg-negative patients, aHR 1.36 (95% CI, 1.03e1.80). HBsAg-positive patients were also more likely to develop Grade 3/4 hepatotoxicity than HBsAg-negative patients, HR 1.99 (1.16e3.40) on survival analysis. There was no significant difference in CD4 responses between HBsAg-positive and HBsAg-negative patients.
Description: An article published by Elsevier Ltd and available at http://dx.doi.org/10.1016/j.jinf.2014.06.012
URI: http://hdl.handle.net/123456789/11887
Appears in Collections:College of Health Sciences

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