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|Title: ||High prevalence of multidrug-resistant tuberculosis among patients with rifampicin resistance using GeneXpert Mycobacterium tuberculosis/rifampicin in Ghana|
|Authors: ||Boakye-Appiah, Justice K.|
Steinmetz, Alexis R.
Phillips, Richard O.
|Keywords: ||GeneXpert GeneXpert MTB/RIF Multidrug-resistant tuberculosis Xpert MTB/RIF|
|Issue Date: ||8-Mar-2016|
|Publisher: ||Elsevier Ltd.|
|Citation: ||Elsevier Ltd 5 ( 2 0 1 6 ) 2 2 6 –2 3 0|
|Abstract: ||Objective/Background: Drug-resistant strains of tuberculosis (TB) represent a major threat to
global TB control. In low- and middle-income countries, resource constraints make it difficult
to identify and monitor cases of resistance using drug susceptibility testing and
culture. Molecular assays such as the GeneXpert Mycobacterium tuberculosis/rifampicin
may prove to be a cost-effective solution to this problem in these settings. The objective
of this study is to evaluate the use of GeneXpert in the diagnosis of pulmonary TB since
it was introduced into two tertiary hospitals in Ghana in 2013.
Methods: A 2-year retrospective audit of clinical cases involving patients who presented
with clinically suspected TB or documented TB not improving on standard therapy and
had samples sent for GeneXpert testing.|
|Description: ||An article published by Elsevier Ltd.|
|Appears in Collections:||College of Health Sciences|
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