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|Title: ||Epidemiology of Mansonella perstans in the middle belt of Ghana|
|Authors: ||Debrah, Linda Batsa|
Phillips, Richard O.
Opoku, Vera Serwaa
|Issue Date: ||2017|
|Publisher: ||Parasites & Vectors|
|Citation: ||Parasites & Vectors DOI 10.1186/s13071-016-1960-0|
|Abstract: ||Background: Mansonellosis was first reported in Ghana by Awadzi in the 1990s. Co-infections of Mansonella
perstans have also been reported in a small cohort of patients with Buruli ulcer and their contacts. However, no
study has assessed the exact prevalence of the disease in a larger study population. This study therefore aimed to
find out the prevalence of M. perstans infection in some districts in Ghana and to determine the diversity of
Culicoides that could be potential vectors for transmission.
Methods: From each participant screened in the Asante Akim North (Ashanti Region), Sene West and Atebubu
Amantin (Brong Ahafo Region) districts, a total of 70 μl of finger prick blood was collected for assessment of M.
perstans microfilariae. Centre for Disease Control (CDC) light traps as well as the Human Landing Catch (HLC)
method were used to assess the species diversity of Culicoides present in the study communities.
Results: From 2,247 participants, an overall prevalence of 32% was recorded although up to 75% prevalence was
demonstrated in some of the communities. Culicoides inornatipennis was the only species of Culicoides caught with
the HLC method. By contrast, C. imicola (47%), C. neavei (25%) and C. schultzei (15%) were caught by the CDC light
trap method. A wide diversity of other Culicoides spp. was also identified but correlation was only found between
the prevalence of C. inornatipennis and M. perstans during the dry season.
Conclusions: Here we demonstrate for the first time that M. perstans is highly prevalent in three districts in Ghana.
We found a wide spectrum of Culicoides spp. Culicoides inornatipennis was the most anthropophilic and is therefore
likely to be the species responsible for transmission of infection but formal proof has yet to be obtained.
Trial registration: NCT02281643. Registered October 26, 2014. ‘Retrospectively registered’. Trial Registry:
|Description: ||An article published by Parasites & Vectors and avlaible at DOI 10.1186/s13071-016-1960-0|
|Appears in Collections:||College of Health Sciences|
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