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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/11816

Title: Combating biofilm and quorum sensing: a new strategy to fight infections
Authors: Danquah, Cynthia Amaning
Osei-Djarbeng, Samuel
Appiah, Theresah
Keywords: biofilm
quorum sensing
bacteria
acyl homoserine lactone
Issue Date: 2018
Publisher: Intech Open
Citation: Intech Open DOI: http://dx.doi.org/10.5772/intechopen.89227
Abstract: Biofilms are structured aggregates of bacterial cells that are embedded in selfproduced extracellular polymeric substances. Various pathogens initiate a disease process by creating organized biofilms that enhance their ability to adhere, replicate to accumulate, and express their virulence potential. Quorum sensing, which refers to the bacterial cell-to-cell communication resulting from production and response to N-acyl homoserine lactone signal molecules, also plays an important role in virulence and biofilm formation. Attenuation of microorganisms’ virulence such that they fail to adapt to the hosts’ environment could be a new strategic fight against pathogens. Thus, agents or products that possess anti-biofilm formation and/or anti-quorum sensing activities could go a long way to manage microbial infections. The incidence of microbial resistance can be reduced by the use of antibiofilm formation and anti-quorum sensing agents.
Description: An article published by Intech Open and available at DOI: http://dx.doi.org/10.5772/intechopen.89227
URI: http://hdl.handle.net/123456789/11816
Appears in Collections:College of Health Sciences

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