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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/11814

Title: Antimicrobial pentacyclic triterpenes and glycosides from the stem bark of Cussonia bancoensis
Authors: Mireku, Evelyn Afua
Mensah, Abraham Yeboah
Amponsah, Isaac Kingsley
Danquah, Cynthia Amaning
Anokwah, Daniel
Baah, Michael Kwesi
Keywords: Cussonia bancoensis
oleanane
ursane
triterpene
antimicrobial
HT-SPOTi
glycoside
Issue Date: 17-Jul-2018
Publisher: Natural Product Research
Citation: Natural Product Research https://doi.org/10.1080/14786419.2018.1503262
Abstract: The stem bark of Cussonia bancoensis is used traditionally for the treatment of different types of infection and pain. A bioassay guided fractionation of the methanol stem bark extract led to the isolation of five pentacyclic triterpenes and glycosides identified based on spectroscopic data as 23-hydroxyursolic acid (CB1), hederagenin (CB2), 3-O-a-L-arabinopyranosyl-echinocystic acid (CB3), 3-O-a-L-arabinopyranosyl- oleanolic acid (CB4) and 3-O-a-Larabinopyranosyl-ursolic acid (CB5). CB2 - CB5 are being reported for the first time from this species. The compounds were evaluated for antimicrobial activity against ten microorganisms using the HT-SPOTi method. CB3 demonstrated remarkable antimicrobial activity against S. aureus, S. pyogens, E. faecalis, S. typhi and C. albicans at MICs between 3.12 and 12.5 mg/mL. Among the studied compounds, it was observed that hydroxylation of position C-16 of the oleanane skeleton may enhance antimicrobial activity. This study gives insight into the anti-infective constituents of the stem bark of C. bancoensis and justifies its use in ethnomedicine.
Description: An article published by Natural Product Research and available at https://doi.org/10.1080/14786419.2018.1503262
URI: http://hdl.handle.net/123456789/11814
Appears in Collections:College of Health Sciences

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