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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/11246

Title: Antimicrobial and anti-inflammatory properties of Funtumia elastica
Authors: Agyare, Christian
Koffuor, George Asumeng
Boakye, Yaw Duah
Mensah, Kwesi Boadu
Keywords: Inflammation
Bacteria
Fungi
Antibacterial
Antifungal
Apocynaceae
Issue Date: 2013
Publisher: Pharmaceutical Biology
Citation: Christian Agyare, George Asumeng Koffuor, Yaw Duah Boakye & Kwesi Boadu Mensah (2013) Antimicrobial and anti-inflammatory properties of Funtumia elastica, Pharmaceutical Biology, 51:4, 418-425, DOI: 10.3109/13880209.2012.738330
Abstract: Context: Funtumia elastica (Preuss) Stapf. (Apocynaceae) has a long ethnopharmacological history for uses such as treatment of whooping cough, asthma, blennorhea, painful menstruation, fungal infections, and wounds. Objective: To investigate the antimicrobial and anti-inflammatory properties of ethanol extracts from the leaves and stem bark of Funtumia elastica based on its ethnopharmacological uses and also determine the secondary metabolites present in the extracts. Materials and methods: The antimicrobial activities of ethanol leaf and bark extracts of F. elastica were determined using the microdilution technique (MIC determination) and agar diffusion method using 10, 25, and 50 mg/mL concentrations against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Candida albicans, Aspergillus flavus and Aspergillus niger as test organisms. Anti-inflammatory activities of the doses of extracts at 30, 100, and 300 mg/kg per body weight were determined by carrageenan-induced edema in the footpad of 7-dayold chicks and the foot volumes measured at hourly interval post-treatment for 5 h. Results: The MIC ranges of both ethanol leaf and bark extracts against the test organisms were 125 (lowest MIC) to1550 μg/mL (highest MIC) and 125 (lowest MIC) to 1750 μg/mL (highest MIC), respectively. The ethanol leaf and bark extract of F. elastica showed significant anti-inflammatory activity (p ≤ 0.001) at 30, 100 and 300 mg/kg. Preliminary phytochemical screening revealed that F. elastica bark contains hydrolysable tannins, sapogenetic glycosides, steroids and saponins while the leaves contain hydrolysable tannins, flavonoids, starch and alkaloids. Tannin contents of the leaf and stem bark were 2.4 and 1.3% w/w (related to the dried material), respectively. Discussion and conclusion: Both ethanol leaf and bark extracts of F. elastica showed antimicrobial and anti-inflammatory activities and these pharmacological properties may be responsible for the ethnomedicinal uses of the leaves and stem bark of the plant.
Description: An article published by Christian Agyare, George Asumeng Koffuor, Yaw Duah Boakye & Kwesi Boadu Mensah (2013) Antimicrobial and anti-inflammatory properties of Funtumia elastica, Pharmaceutical Biology, 51:4, 418-425, DOI: 10.3109/13880209.2012.738330
URI: http://hdl.handle.net/123456789/11246
Appears in Collections:College of Health Sciences

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