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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/11038

Title: Review: African medicinal plants with wound healing properties
Authors: Agyare, Christian
Boakye, Yaw Duah
Bekoe, Emelia Oppong
Hensel, Andreas
Dapaah, Susana Oteng
Appiah, Theresa
Keywords: African medicinal plants
Wound models
Antioxidant
Antimicrobial
Wound healing activity
Issue Date: 2015
Publisher: Journal of Ethnopharmacology
Citation: Christian Agyare, Yaw Duah Boakye, Emelia Oppong Bekoe, Andreas Hensel, Susana Oteng Dapaah and Theresa Appiah, Review: African medicinal plants with wound healing properties, Journal of Ethnopharmacology, http://dx.doi.org/10.1016/j.jep.2015.11.008
Abstract: Ethnopharmacological relevance: Wounds of various types including injuries, cuts, pressure, burns, diabetic, gastric and duodenal ulcers continue to have severe socio-economic impact on the cost of health care to patients, family and health care institutions in both developing and developed countries. However, most people in the developing countries, especially Africa, depend on herbal remedies for effective treatment of wounds. Various in vitro and in vivo parameters are used for the evaluation of the functional activity of medicinal plants by using extracts, fractions and isolated compounds. The aim of the review is to identify African medicinal plants with wound healing properties within the last two decades. Materials and methods: Electronic databases such as PubMed, Scifinder┬« and Google Scholar were used to search and filter for African medicinal plants with wound healing activity. The methods employed in the evaluation of wound healing activity of these African medicinal plants comprise both in vivo and in vitro models. In vivo wound models such as excision, incision, dead space and burn wound model are commonly employed in assessing the rate of wound closure (contraction), tensile strength or breaking strength determination, antioxidant and antimicrobial activities, hydroxyproline content assay and histological investigations including epithelialisation, collagen synthesis, and granulation tissue formation. In in vitro studies, single 2 cell systems are mostly used to study proliferation and differentiation of dermal fibroblasts and keratinocytes by monitoring typical differentiation markers like collagen and keratin. Results: In this study, 61 plants belonging to 36 families with scientifically demonstrated or reported wound healing properties were reviewed. Various plant parts including leaves, fruits, stem bark and root extracts of the plants are used in the evaluation of plants for wound healing activities. Conclusion: Although, a variety of medicinal plants for wound healing can be found in literature, there is a need for the isolation and characterization of the bioactive compounds responsible for the wound healing properties. Also, cytotoxicity studies should be performed on the promising agents or bioactive fractions or extracts.
Description: An article published by Christian Agyare, Yaw Duah Boakye, Emelia Oppong Bekoe, Andreas Hensel, Susana Oteng Dapaah and Theresa Appiah, Review: African medicinal plants with wound healing properties, Journal of Ethnopharmacology, http://dx.doi.org/10.1016/j.jep.2015.11.008
URI: http://hdl.handle.net/123456789/11038
Appears in Collections:College of Health Sciences

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