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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/11034

Title: A Hydroalcoholic Extract from Paullinia pinnata L. Roots Exerts Anthelmintic Activity against Free-Living and Parasitic Nematodes
Authors: Spiegler, Verena
Liebau, Eva
Peppler, Carolin
Raue, Katharina
Werne, Steffen
Strube, Christina
Heckendorn, Felix
Agyare, Christian
Stark, Timo
Hofmann, Thomas
Hensel, Andreas
Keywords: Paullinia pinnata
Sapindaceae
Caenorhabditis elegans
Toxocara cat
Trichuris vulpis
Ancylostoma caninum
Issue Date: 2016
Publisher: Planta Med.
Citation: Planta Med., 2016
Abstract: Paullinia pinnata is amedicinal plant traditionally used in West Africa against a wide range of diseases including soil-transmitted helminthiases. In this study, a hydroethanolic root extract was investigated for its phytochemical composition and in vitro activity against the free-living nematode Caenorhabditis elegans as well as the larval stages of the parasitic helminths Ancylostoma caninum, Haemonchus contortus, Toxocara cati, and Trichuris vulpis. LC‑MS analysis of the ethanol-water (1 :1) extract revealed epicatechin and different A-type linked oligomeric and polymeric procyanidins as the predominant compounds. Within an in vitro mortality assay, the extract showed a lethal activity against T. cati (LC50 of 112 μg/mL), T. vulpis (LC50 of 17 μg/mL), and C. elegans (LC50 2.5 of mg/mL), but not against A. caninum. Additionally, effects on egg hatching and larval migration of H. contortus were investigated, but no inhibitory activity was observed. Overall, these findings rationalize the traditional use of the root extract from P. pinnata as an anthelmintic remedy and provide insight into the phytochemical composition of the extract.
Description: An article published by Planta Med.,2016
URI: http://hdl.handle.net/123456789/11034
Appears in Collections:College of Health Sciences

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