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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/10985

Title: Flavonoid glycosides from the stem bark of Margaritaria discoideademonstrate antibacterial and free radical scavenging activities
Authors: Ekuadzi, Edmund
Gibbons, Simon
Dickson, Rita
Fleischer, Theophilus
Annan, Kofi
Pistorius, Dominik
Oberer, Lukas
Keywords: antibacterial activities
antioxidant activities
Margaritaria discoidea
flavonoid glycosides
margadiscoside
fagovatin
Issue Date: 22-Aug-2013
Publisher: Wiley Online Library
Citation: Phytother. Res.28: 784–787 (2014)
Abstract: One new f lavonoid glycoside, along with three known f lavonoid glycosides were isolated from the stem bark of Margaritaria discoidea, which is traditionally used in the management of wounds and skin infections in Ghana. The new flavonoid glycoside was elucidated as hydroxygenkwanin-8-C-[α-rhamnopyranosyl-(1→6)]-β-glucopyranoside (1) on the basis of spectroscopic analysis. The isolated compounds demonstrated free-radical scavenging as well as some level of antibacterial activities. Microorganisms including Staphylococcus aureus are implicated in inhibiting or delaying wound healing. Therefore, any agent capable of reducing or eliminating the microbial load present in a wound as well as decreasing the levels of reactive oxygen species may facilitate the healing process. These findings therefore provide some support to the ethnopharmacological usage of the plant in the management of wounds.
Description: This article was published in Phytother. Res.28: 784–787 (2014)
URI: http://hdl.handle.net/123456789/10985
Appears in Collections:College of Health Sciences

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