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|Title: ||Antibacterial, anti-inflammatory and antioxidant properties of gouania longipetala hemsl|
|Authors: ||Ekuadzi, Edmund|
Fleischer, Theophilus C.
Dickson, Rita A.
|Keywords: ||Ghanaian medicinal plants|
|Issue Date: ||2012|
|Citation: ||Ekuadzi et al., IJPSR, 2012; Vol. 3(5): 1300-1305|
|Abstract: ||Background: Gouania longipetala Hemsl. (Rhamnaceae), has ethnomedicinal
use in the treatment of wounds, gonorrhoea, abdominal pain, lumbago,
ophthalmia, conjunctivitis, and rickets. However, no scientific investigation of
these effects has been established. Our aim was to verify the antibacterial,
antioxidant and anti-inflammatory effects of the stem of Gouania
Methods: The antibacterial effect of the 70% ethanolic extract was studied
using the agar well diffusion and micro dilution assays. The extract was also
tested in vitro for its free radical scavenging effect, total antioxidant capacity
and total phenol content. The extract activity in acute inflammation was
assessed using the carrageenan-induced foot oedema in chicks.
Results: The 70% ethanollic extract showed antibacterial effect against the
test organisms with the lowest MIC of 125 µg/mL against Bacillus subtilis
NCTC 10073. The total antioxidant capacity was 0.80 mg/g ascorbic acid
equivalent. The extract demonstrated free radical scavenging activity yielding
value of 0.004 mg/mL. In the total phenol content assay, tannic acid
equivalent was 52.02mg/g and correlated highly with its total antioxidant
capacity. In the anti-inflammatory assay, the extract gave a maximal
inhibitory effect of total oedema by 93.78% at 300 mg/kg.
Conclusions: The results indicated that the extract possessed antibacterial,
antioxidant and anti-inflammatory properties and may give credence to
some of its ethnopharmacological uses.|
|Description: ||This article was published in Ekuadzi et al., IJPSR, 2012; Vol. 3(5): 1300-1305|
|Appears in Collections:||College of Health Sciences|
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