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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/10962

Title: Acute and sub-chronic toxicity of aqueous ethanolic extract of Ficus pumila leaves in rats
Authors: Larbie, Christopher
Osei, Asibey
Owusu, Kofi Poku
Torkornoo, Dennis
Keywords: haematology
biochemical parameters
Ficus pumila
subchronic toxicity
Issue Date: 2016
Publisher: European Journal of Biomedical and Pharmaceutical Sciences
Citation: ejbps, 2016, Volume 3, Issue 8, 22-27.
Abstract: Ficus pumila (creeping fig) is a popular ornamental plant in the tropical region. Its reported ethnomedical uses include the treatment of impotence and menstrual disorders and shown to have significant antioxidant and antiproliferative activity. In an attempt to certify safety and support its medical and healthcare use, acute and subchronic toxicity studies were carried out on the hydroethanolic leaf extracts of Ficus pumila in animals at doses of 100 mg/kg, 250 mg/kg and 500 mg/kg body weight using standard methods. Control group received 1 ml of normal saline. Haematological parameters, plasma biochemical parameters and physical evaluations of vital organs were carried out after the experimental period of 28 days in subchronic study. The median acute toxicity (LD50) values of extract was determined to be <5 g/kg body weight in mice. Observations after sub-chronic toxicity included hypolipidaemia, increased ALP at higher doses and normal creatine and urea levels. The extract did not produce any toxic effect on vital organs except decreases in uterus weight in female rats. Hydroethanolic extract of F. pumila could be considered safe at moderate doses.
Description: This article was published in the ejbps, 2016, Volume 3, Issue 8, 22-27.
URI: http://hdl.handle.net/123456789/10962
ISSN: 2349-8870
Appears in Collections:College of Science

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