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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/10961

Title: Anti-proliferative effect of Amaranthus Viridis Linn. on human leukemic cell lines- a preliminary study
Authors: Larbie, Christopher
Abotsi, Perfect
Appiah-Opong, Regina
Acheampong, Felix
Tuffour, Isaac
Uto, Takuhiro
Torkornoo, Dennis
Marfo, Edward
Ankamah-Mensah, Daniel
Opoku-Mensah, Eunice
Keywords: Phenolic
Phytochemical
Anti-proliferative
Antioxidant
Amaranthus viridis Linn
Issue Date: 2015
Publisher: International Journal of Biological & Pharmaceutical Research
Citation: Larbie Christopher. et al. / International Journal of Biological & Pharmaceutical Research. 2015; 6(3): 236-243
Abstract: The aim of this study was to evaluate the phytochemical and total phenolic content, the antioxidant and anti-proliferative effects of 50% ethanolic extracts of Amaranthus virdis Linn. leaves (AVL) and stem (AVS), using standard methods. Phytochemical analysis showed that the aqueous ethanolic extracts from the stems and leaves were rich in tannins, saponins, general glycosides, alkaloids and terpenoids. The leaf extract showed a significantly higher phenolic content and higher antioxidant activity compared to the stem extracts. From the MTT assay, it was observed that all the extracts had anti-proliferative activity against 3 human leukemic cell lines (Jurkat, CEM and HL-60). The AVL had IC50 value of 111.41 µg/ml (JURKAT), 122.5 µg/ml (HL-60) and >1000 µg/ml (CEM). The AVS had comparatively lower anti-proliferative activity with IC50 values of 651.52 µg/ml (JURKAT), 813.5 µg/ml (HL-60) and >1000 μg/ml (CEM). It was also observed that, both extracts enhanced the proliferation of normal cells while the standard curcumin had an anti-proliferative effect on both leukemic and normal cells. It can be concluded that the AVL had better antioxidant and anti-proliferative effect and could further be explored as a novel source of cancer therapy.
Description: This article was published in the Larbie Christopher. et al. / International Journal of Biological & Pharmaceutical Research. 2015; 6(3): 236-243
URI: http://hdl.handle.net/123456789/10961
Appears in Collections:College of Science

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