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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/10706

Title: Effects of hyrdroethanolic leaf extract of Pseudospondias microcarpa (A. Rich.) Engl. (Anacardiaceae) on the central nervous system in mice
Authors: Adongo, Donatus Wewura
Mante, Priscilla Kolibea
Woode, Eric
Ameyaw, Elvis Ofori
Kukuia, Kennedy Kwami Edem
Keywords: Analgesia
CNS depressant
Irwin test
Pentobarbitone (PBT)
Pseudospondias microcarpa (PME)
Issue Date: 2014
Publisher: The Journal of Phytopharmacology
Citation: The Journal of Phytopharmacology 2014; 3(6): 410-417
Abstract: Pseudospondias microcarpa (Anacardiaceae), the African grape tree, is used for various CNS disorders. The neuropharmacological activities of the hydroethanolic leaf extract of Pseudospondias microcarpa (PME) were screened in mice. In this study, the central nervous system (CNS) activity was tested in various animal models including Irwin test, pentobarbitone-induced sleeping time, spontaneous motor activity, rotarod test, pentylenetetrazole-induced convulsions and tail immersion test. The extract produced sedation and analgesia in the Irwin test with an LD50 above 3000 mg kg-1. PME potentiated pentobarbitone sleeping time and induced hepatic enzymes. It however, showed no effect on locomotor activity or motor coordination. Furthermore, the extract blocked convulsions induced by PTZ and showed analgesic activity in the tail withdrawal test. The present investigation suggests that PME may act as a sedative with analgesic and anticonvulsant activity, and thus supporting its use as a sedative and for the relief of various nervous system disorders.
Description: An article published by The Journal of Phytopharmacology 2014; 3(6): 410-417
URI: http://hdl.handle.net/123456789/10706
Appears in Collections:College of Health Sciences

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