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|Title: ||Anti-inflammatory and anti-oxidant activities of Secamone afzelii (Rhoem) Ascleipiadaceae|
|Authors: ||Mensah, A. Y.|
Mireku, E. A.
|Keywords: ||Secamone afzelii, carrageenan|
|Issue Date: ||2014|
|Publisher: ||Journal of Medical and Biomedical Sciences|
|Citation: ||Journal of Medical and Biomedical Sciences (2014) 3(1): 23-30|
|Abstract: ||Secamone afzelii is used traditionally in Ghana mainly as a wound healing agent. This study re-ports the anti-inflammatory and antioxidant properties of S. afzelii. The anti-inflammatory activity was determined by the carrageenan-induced paw oedema method in 7 day old chicks and antioxi-dant property by the 2,2–diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, total antioxi-dant and total phenol content determinations. In doses of 30, 100 and 300 mg kg-1, the methanol extract of the leaves reduced carrageenan-induced oedema by 24.70%, 33.41% and 44.26% respec-tively. The leaf extract exhibited free radical scavenging activity with an IC50 of 16.73 μg mL-1 com-pared to ascorbic acid which gave an IC50 of 2.01 μg mL-1. In the total phenol content determina-tion, the leaf extract was found to contain 56.86 mg g-1 calculated as tannic acid equivalent of the dry weight of extract. The extract also demonstrated remarkable antioxidant effect in the total anti-oxidant capacity determinations and had an 87% correlation with the amount of phenolic content present.|
|Description: ||n article published by Journal of Medical and Biomedical Sciences (2014) 3(1): 23-30, doi: http://dx.doi.org/10.4314/jmbs.v3i1.4|
|Appears in Collections:||College of Health Sciences|
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