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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/10689

Title: Antiplasmodial constituents from the stem bark of Polyalthia longifolia var pendula
Authors: Annan, Kofi
Ekuadzi, E.
Asare, Cindy
Sarpong, Kwame
Pistorius, Dominik
Oberer, Lukas
Gyan, Ben A.
Ofori, Michael
Keywords: Clerodane
Polyalthia longifolia
Bisclerodane imide
Issue Date: 2015
Publisher: Phytochemistry Letters
Citation: Phytochemistry Letters 11 (2015) 28–31
Abstract: Along with two known compounds (1 and 2), four new clerodane diterpenes were isolated and identified from the stem bark of Polyalthia longifolia: cleroda-3-ene pyrrole-15,16-dione (3), cleroda-3-ene, pyrrolidine-15,16-dione (4), cleroda-3,13(14)E-diene-15,16-diamide (5), and cleroda-3-ene-15, 16-diamide (6). Their structures were elucidated by combinations of NMR, MS and IR. Using the WHO Mark III Microtest assay, the isolated compounds were evaluated for their antiplasmodial effects. They showed antiplasmodial effects, with IC50s ranging from 4.5 to 213.8 mM.
Description: An article published by Phytochemistry Letters 11 (2015) 28–31
URI: http://hdl.handle.net/123456789/10689
Appears in Collections:College of Health Sciences

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